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Change in substantial holding

Announced by: SIP
Announced on: 13/11/2009 11:47:00
          Words: 1593
Status: Not market sensitive (N)
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Barclays Global Investors Australia
Form 604 page 1 of 2
Form 604
Corporations Act 2001
Section 671B
Notice of change of interests of substantial holder

To
Sigma Pharmaceuticals Limited (SIP)
ACN/ARSN
088 417 403

1. Details of substantial holder

Name
Barclays Group lodged by Barclays Global Investors Australia Limited
ABN
33 001 804 566 (Barclays Global Investors Australia Limited)

There was a change in the interests of the substantial holder on
11 November 2009

The previous notice was given to the company on
06 October 2009

The previous notice was dated
06 October 2009

2. Previous and present voting power

The total number of votes attached to all the voting shares in the company or voting interests in the scheme that
the substantial holder an associate had a relevant interest in when last required, and when now required, to give
a substantial holding notice to the company or scheme, are as follows:
Class of securities
Previous notice
Present notice
Person's votes
Voting power
Person's votes
Voting power
Ordinary 66,814,925
6.64% 65,525,166
5.62%

3. Changes in relevant interests

Particulars of each change in, or change on the nature of, a relevant interest of the substantial holder or an
associate in voting securities of the company or scheme, since the substantial holder was last required to give a
substantial holding notice to the company or scheme are as follows:
Date of
change
Person whose
relevant interest
changed
Nature of
change
Consideration
given in relation to
change
Class and number
of securities
Affected
Person's
votes
affected
11/11/09
Barclays Group
Decrease in
voting power
Average price
$0.983
Ordinary
(1,289,759)
(1.02)%

4. Present relevant interests

Particulars of each relevant interest of the substantial holder in voting securities after the change are as follows:
Holder of
relevant interest
Registered holder of securities
Nature of
relevant interest
Class and
number of
securities
Person's
votes
Barclays Group
JP Morgan & other custodians ­
See Annexure "A"
Annexure "A"
65,525,166
5.62%
5. Addresses

The addresses of persons named in this form are as follows:
Name
Address
Barclays Global Investors Australia Limited
Level 43, 225 George Street, Sydney NSW 2000

Signature


_________________________________
13 November 2009
Company
Secretary
Date
Barclays Global Investors Australia
Barclays Global Investors Australia
Form 604 page 2 of 2
This is "Annexure A" of 1 page referred to in Form 604 Notice of
change of interests of substantial holder
Relevant interest in Sigma Pharmaceuticals Limited ("SIP") held by members of the Barclays Group.

The list of Barclays entities and their respective holdings are as follows:
ASX
CODE
STOCK NAME
COMPANY
HOLDING
%
SIP
Sigma Pharmaceuticals Limited
Barclays Global Investors Japan Ltd
195,654
0.02
SIP
Sigma Pharmaceuticals Limited
Barclays Global Investors Ltd
2,620,202
0.22
SIP
Sigma Pharmaceuticals Limited
Barclays Bank PLC
253,955
0.02
SIP
Sigma Pharmaceuticals Limited
Barclays Global Investors Ltd
3,355,677
0.29
SIP
Sigma Pharmaceuticals Limited
Barclays Global Investors, N.A.
3,299,734
0.28
SIP
Sigma Pharmaceuticals Limited
Barclays Global Fund Advisors
1,259,585
0.11
SIP
Sigma Pharmaceuticals Limited
Barclays Capital Securities Ltd
659,294
0.06
SIP
Sigma Pharmaceuticals Limited
Barclays Global Investors Canada Ltd
205,329
0.02
SIP
Sigma Pharmaceuticals Limited
Barclays Global Investors Australia Ltd
53,675,736
4.6
65,525,166 5.62


The JP Morgan Chase Bank Inc. and various other custodians (Custodians) hold shares in SIP as custodian and
for which the members of the Barclays Group are either:
·
the responsible entity or trustee of pooled investment products such as registered managed investment
schemes (Funds); or
·
the investment manager of Portfolios held for a number of institutional investors. The institutional
investors are generally superannuation funds regulated under the Superannuation Industry Supervision
Act 1993
.

The holding of shares in SIP was acquired as part of the wide portfolio of Australian shares and units acquired for
the Funds and the Portfolios.

The members of the Barclays Group and the Custodians may hold relevant interests due to the capacity of these
entities to dispose of the shares in SIP.

Each investor in a Fund owns an undivided interest in the Fund's assets, no client directly owns any asset of the
Fund. The unitholding of each Fund varies from time to time as clients enter and withdraw from the Funds. The
various institutional investors with portfolios delegate the management of the portfolios to the members of the
Barclays Group.



___________________________ 13 November 2009
Company Secretary
Date
Barclays
Global
Investors Australia

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